Board, PhilipCoggan, MarjorieChelvanayagam, GarethEasteal, SimonJermiin, Lars SommerSchulte, JurgenDanley, DHoth, LGriffor, MKamath, ARosner, MChrunyk, BPerregaux, DGabel, CGatens, MoiraPandit, J2015-12-132015-12-130009-2797http://hdl.handle.net/1885/90731The Omega class of glutathione transferases (GST) has been discovered by analysis of the expressed sequence tag database and sequence alignment. In humans, GSTO 1-1 is expressed in most tissues and exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities characteristic of the glutaredoxins. The crystal structure indicates that GSTO 1-1 has a characteristic GST fold. Unlike other mammalian glutathione transferases, GSTO 1-1 appears to have an active site cysteine that can form a disulfide bond with glutathione.Keywords: Glutathione transferase superfamily; Omega class; X-ray crystallography20012015-12-12