Assembly of polyamines via amino acids from three components using cobalt(III) template methodology.

Laval, GillesClegg, WilliamCrane, ChristopherHammershoi, AndersSargeson, AlanGolding, Bernard2015-12-132015-12-131359-7345http://hdl.handle.net/1885/72562A versatile and efficient template synthesis has been developed to synthesise novel polyamines [e.g. rac-N3-(3-aminopropyl)butane-1,3-diamine, isospermidine 1] via amino acids [e.g. (2R,4S/2S,4R)-N4-(3-aminopropyl)-2,4-di-aminopentanoic acid] using cobalt(III) to assemble the three precursor components in a biomimetic manner.Keywords: cobalt; n 3 (aminopropyl)butane 1,3 diamine; n 4 (3 aminopropyl) 2,4 diaminopentanoic acid; polyamine derivative; spermidine derivative; unclassified drug; valeric acid derivative; article; biomimetics; drug structure; drug synthesis; methodology; precursAssembly of polyamines via amino acids from three components using cobalt(III) template methodology.200210.1039/b206462f2015-12-11