Kelly, John JTam, Sim HomWilliamson, Paula MWhitworth, Judith2015-12-070305-1870http://hdl.handle.net/1885/211851. Decreased nitric oxide (NO) availability is thought to be a feature of cortisol-induced hypertension in humans. 2. We hypothesized that, accordingly, the threshold for a depressor response to NO should be decreased by cortisol treatment. 3. We re-analysed data from a study of baroreflex function in normal men treated with cortisol using glyceryl trinitrate (GTN). 4. Cortisol treatment increased blood pressure and decreased the threshold dose of GTN for a fall in systolic and mean blood pressure. 5. These data support the notion that glucorticoid hypertension is associated with reduced NO bioavailability.Keywords: glyceryl trinitrate; hydrocortisone; nitric oxide donor; adult; article; blood pressure monitoring; clinical article; controlled study; human; hypertension; male; mean arterial pressure; pressoreceptor reflex; systolic blood pressure; Adult; Blood Pressur Blood pressure; Cortisol; Glucocorticoids; Glyceryl trinitrate; Humans; Nitric oxide200710.1111/j.1440-1681.2007.04700.x2015-12-07