Hemmings, Christine2015-12-100031-3025http://hdl.handle.net/1885/52670The cancer stem cell hypothesis suggests that malignant tumours may arise from a limited number of specialised cells possessing the key 'stem' properties of self-renewal and the ability to produce differentiated progeny. Such cells purportedly constituteKeywords: tumor marker; animal; article; cancer stem cell; cell transformation; disease model; drug therapy; female; human; male; metabolism; mouse; neoplasm; pathology; radiotherapy; tumor recurrence; Animals; Cell Transformation, Neoplastic; Disease Models, Anima Cancer; Cancer-initiating cells; Niche; Stem cell; Tumour stroma; Tumourigenesis201010.3109/003130209034887732016-02-24