T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells

Herlands, Robin A.Christensen, Sean R.Sweet, RebeccaHershberg, UriShlomchik, M J2015-12-101074-7613http://hdl.handle.net/1885/49985On the lupus-prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of follicles. Using multiple strategies to impair T cells, we found that suKeywords: autoantibody; immunoglobulin G; ligand; myeloid differentiation factor 88; toll like receptor; toll like receptor 7; toll like receptor 9; animal experiment; article; B lymphocyte; B lymphocyte activation; cell differentiation; cell expansion; cell prolif CELLIMMUNO; MOLIMMUNOT Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells200810.1016/j.immuni.2008.06.0092015-12-09