How do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids

Whitworth, JudithOng, Lee Lin (Sharon)2015-12-100889-8529http://hdl.handle.net/1885/69884The exact mechanism by which glucocorticoid induces hypertension is unclear. Several mechanisms have been proposed, although there is evidence against the role of sodium and water retention as well as sympathetic nerve activation. This review highlights the role of nitric oxide-redox imbalance and their interactions with arachidonic acid metabolism in glucocorticoid-induced hypertension in humans and experimental animal models.Keywords: acetylcysteine; acetylsalicylic acid; angiotensin II; apocynin; arginine; argipressin; atenolol; atorvastatin; corticotropin; dexamethasone; endothelin; felodipine; folic acid; glucocorticoid; guanosine triphosphate cyclohydrolase I; hydrocortisone; icosa 20-hydroxyeicosatetranoic acid; Glucocorticoid; Hypertension; Nitric oxide; Oxidative stress; ProstanoidsHow do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids201110.1016/j.ecl.2011.01.0102016-02-24