Sheikh, FaisalIsmail, ZahinoorMortby, MoyraBarber, PhilipCieslak, AlicjaFischer, KarynGranger, RobertHogan, David BMackie, AaronMaxwell, J, Colleen2019-07-081041-6102http://hdl.handle.net/1885/164400Background: Mild behavioral impairment (MBI) describes later life acquired, sustained neuropsychiatric symptoms (NPS) in cognitively normal individuals or those with mild cognitive impairment (MCI), as an at-risk state for incident cognitive decline and dementia. We developed an operational definition of MBI and tested whether the presence of MBI was related to caregiver burden in patients with subjective cognitive decline (SCD) or MCI assessed at a memory clinic. Methods: MBI was assessed in 282 consecutive memory clinic patients with SCD (n = 119) or MCI (n = 163) in accordance with the International Society to Advance Alzheimer's Research and Treatment – Alzheimer's Association (ISTAART–AA) research diagnostic criteria. We operationalized a definition of MBI using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Caregiver burden was assessed using the Zarit caregiver burden scale. Generalized linear regression was used to model the effect of MBI domains on caregiver burden. Results: While MBI was more prevalent in MCI (85.3%) than in SCD (76.5%), this difference was not statistically significant (p = 0.06). Prevalence estimates across MBI domains were affective dysregulation (77.8%); impulse control (64.4%); decreased motivation (51.7%); social inappropriateness (27.8%); and abnormal perception or thought content (8.7%). Affective dysregulation (p = 0.03) and decreased motivation (p=0.01) were more prevalent in MCI than SCD patients. Caregiver burden was 3.35 times higher when MBI was present after controlling for age, education, sex, and MCI (p < 0.0001). Conclusions: MBI was common in memory clinic patients without dementia and was associated with greater caregiver burden. These data show that MBI is a common and clinically relevant syndrome.We would like to acknowledge the support of the Ron and Irene Ward foundation, the Taylor family foundation, the Clinician Engagement Grant from the Addiction and Mental Health Strategic Clinical Network of Alberta Health Services, and the Alzheimer’s Society of Calgary, via the Hotchkiss Brain Institute. M. E. Mortby is supported by the Australian National Health and Medical Research Council (NHMRC) and Australian Research Council (ARC) Dementia Research Development Fellowship #1102028.application/pdfen-AU© 2017 International Psychogeriatric Associationmild behavioral impairment (MBI)mild cognitive impairment (MCI)caregiver burdensubjective cognitive declinememory clinicprodromal dementia2017-09-0710.1017/S104161021700151X2022-05-15