Ong, KevinVillemagne, Victor L.Bahar-Fuchs, AlexLamb, FionaChetelat, GaelRaniga, ParneshMulligan, Rachel S.Salvado, OlivierPutz, BarbaraRoth, KatrinMasters, Colin L.Reininger, Cornelia B.Rowe, Christopher C.2014-05-012014-05-011758-91931758-9193http://hdl.handle.net/1885/11600F-florbetaben and positron emission tomography were used to examine the relationships between b-amyloid (Ab) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).Methods: Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Ab burden. Correlations were adjusted for age, gender and years of education.Results: High A b burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r= -0.51,P= 0.0015) and hippocampal volume (r= 0.60,P= 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Ab burden.Conclusion: Higher Ab deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.11 pageshttp://www.sherpa.ac.uk/romeo/issn/1758-9193/ Author can archive pre-print (ie pre-refereeing); author can archive post-print (ie final draft post-refereeing);author can archive publisher's version/PDF;Creative Commons Attribution Licence;Copy of License must accompany any depositAlzheimers association workgroupsneurofibrillary tanglesamyloid depositionwhite-matterin-vivodiagnostic guidelinesnational institutesenile dementiacompound-bdisease201310.1186/alzrt1582015-12-09