Lee, ConnieEaston, ChristopherSavage, G PaulSimpson, Gregory Wayne2015-12-131551-7004http://hdl.handle.net/1885/79744Four spiroisoxazolines have been prepared, by cycloaddition of aceto-, pivalo-, benzo- and mesito-nitrile oxide with 3-methylenequinuclidine. The reactions were completely regioselective, within the limits of detection. None of the isoxazolines showed significant inhibition of acetylcholinesterase.Keywords: Acetylcholinesterase; Alzheimer's disease; Cycloadditions; Isoxazolines; Nitrile oxides; Quinuclidine20062015-12-11