Paterson, IanBower, ShelleyMcLeod, Malcolm D.2026-01-072026-01-070040-4039https://hdl.handle.net/1885/733803918A boron-mediated, syn-aldol coupling between ethyl ketone 8 and aldehyde 9, followed by directed hydrogenation at C16 and acetonide hydrolysis, gives the C13C25 segment 6 of bafilomycin A1.Acknowledgement: We thank the EPSRC (GR/J63019), EC (HCM Network CHRXCT930141), Pfizer Central Research, Cambridge Commonwealth Trust and Selwyn College for their support.4enStereocontrolled aldol additions to α-methylene-β-alkoxy aldehydes: Application to the synthesis of a C<sub>13</sub>C<sub>25</sub> segment of bafilomycin A<sub>1</sub>1995-01-0210.1016/0040-4039(94)02205-P0028891048