Lin, Hsiao-ChingChooi, Yit-HengDhingra, SourabhXu, WeiCalvo, Ana MTang, Yi2015-12-130002-7863http://hdl.handle.net/1885/81463Fumagillin 1 is a meroterpenoid from Aspergillus fumigatus that is known for its anti-angiogenic activity by binding to human methionine aminopeptidase 2. The genetic and molecular basis for biosynthesis of 1 had been an enigma despite the availability ofKeywords: Acyltransferase; Anti-angiogenic activity; Aspergillus fumigatus; Biosynthetic gene cluster; Genome sequences; Methionine aminopeptidase; Molecular basis; Polyketide synthases; Amino acids; Aspergillus; Biochemistry; Biosynthesis; Plants (botany); TerpeneThe fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of -trans-bergamotene201310.1021/ja312503y2016-02-24