Finite element modeling of optic chiasmal compression

Abstract

Background: The precise mechanism of bitemporal hemi-anopia is still not clear. Our study investigated the mechanism of bitemporal hemianopia by studying the biomechanics of chiasmal compression caused by a pitui-tary tumor growing below the optic chiasm.Methods: Chiasmal compression and nerve fiber interaction in the chiasm were simulated numerically using finite element modeling software. Detailed mechanical strain distributions in the chiasm were obtained to help understand the mechanical behavior of the optic chiasm. Nerve fiber models were built to determine the relative difference in strain experienced by crossed and uncrossed nerve fibers.Results: The central aspect of the chiasm always experi-enced higher strains than the peripheral aspect when the chiasm was loaded centrally from beneath. Strains in the nasal (crossed) nerve fibers were dramatically higher than in temporal (uncrossed) nerve fibers.Conclusions: The simulation results of the macroscopic chiasmal model are in agreement with the limited experimental results available, suggesting that the finite element method is an appropriate tool for analyzing chiasmal compression. Although the microscopic nerve fiber model was unvalidated because of lack of experimental data, it provided useful insights into a possible mechanism of bitemporal hemianopia. Specif-ically, it showed that the strain difference between crossed and uncrossed nerve fibers may account for the selective nerve damage, which gives rise to bitemporal hemianopia. Show more