Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in aspergillus nidulans

Yin, Wen-Bing; Chooi, Yit-Heng; Smith, Adam R; Cacho, Ralph A; Hu, Youcai; White, Theodore C; Tang, Yi

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Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in aspergillus nidulans

Date

2013

Authors

Yin, Wen-Bing

Chooi, Yit-Heng

Smith, Adam R

Cacho, Ralph A

Hu, Youcai

White, Theodore C

Tang, Yi

Publisher

American Chemical Society

Abstract

Dermatophytes belonging to the Trichophyton and Arthroderma genera cause skin infections in humans and animals. From genome sequencing data, we mined a conserved gene cluster among dermatophytes that are homologous to one that produces an immunosuppressiv