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Identification of active site residues of the pro-metastatic endoglycosidase heparanase

Date

Authors

Hulett, Mark

Hornby, June

Ohms, Stephen J

Zuegg, J.

Freeman, Craig

Gready, Jill

Parish, Christopher

Publisher

American Chemical Society

Abstract

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate (HS) and has been implicated in many important physiological and pathological processes, including tumor cell metastasis, angiogenesis, and leukocyte migration. We report herein the ident

Keywords

Keywords: alanine; beta glucuronidase; endoglycosidase heparanase; glutamic acid; glycosidase; heparan sulfate; heparanase; proton; unclassified drug; angiogenesis; animal cell; article; enzyme active site; enzyme activity; leukocyte migration; metastasis; monkey; Author Keywords

URI

http://hdl.handle.net/1885/88929

Collections

ANU Research Publications

Source

Biochemistry

Type

Journal article

DOI

10.1021/bi002080p

Restricted until

2037-12-31

Downloads

File

Description

01_Hulett_Identification_of_active_site_2000.pdf (256.03 KB)

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