Filigree Vascular Pattern in Combined Hamartoma of Retina and Retinal Pigment Epithelium on OCT Angiography

Date

2019

Authors

Gupta, Rajan
Pappuru, Rajeev R.
Fung, K. Adrian T.
Lupidi, Marco
Kaliki, Swathi
Yannuzzi, Lawrence
Freund, K. Bailey
Reid, Kate
Zur, Dinah
Iglicki, Matias

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier Inc.

Abstract

Purpose To evaluate the vascular structure within combined hamartoma of retina and retinal pigment epithelium (CHRRPE) lesions using OCT angiography (OCTA). Design Multicenter, retrospective, observational analysis, Participants Twenty eyes of patients diagnosed with CHRRPE. Methods Retrospective analysis of color fundus photographs, OCT, and OCTA of 20 eyes with CHRRPE. Morphologic characteristics of CHRRPE and the OCT features were correlated with the density of the filigree vascular pattern and with the published histopathologic findings of CHRRPE lesions. Main Outcome Measure Density of flow signals, that is, the filigree vascular pattern seen on OCTA in the deep capillary plexus, graded as high (>20), intermediate (10–20), or low (<10). Results Of 20 lesions, 11 were peripapillary, 8 were macular, and 1 was equatorial in location. A high density of filigree vascular pattern was observed in most peripapillary CHRRPE lesions, which also showed full-thickness retinal involvement (8/10). A low density of filigree pattern was seen in macular lesions, which showed partial-thickness retinal involvement and preretinal fibrosis (5/6). Conclusions A filigree vascular pattern on OCTA is seen in CHRRPE lesions. High density of this pattern is noted in CHRRPE lesions with a peripapillary location, full-thickness retinal disorganization, and minimal preretinal fibrosis. These findings correlate well with published histopathologic findings of CHRRPE lesions both in terms of topographic and morphologic features. OCT angiography provides a promising method for further study of these lesions.

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Citation

Source

Ophthalmology Retina

Type

Journal article

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DOI

10.1016/j.oret.2019.04.024

Restricted until

2099-12-31