Biochemical and Functional Characterization of Human Transmembrane Tryptase(TMT)Ttryptase g.

Wong, Guang; Foster, Paul S; Yasuda, Shinsuke; Qi, Jian; Mahalingam, Surendran; Mellor, Elizabeth; Katsoulotos, Gregory; Li, Lixin; Boyce, Joshua; Krilis, Steven; Stevens, Richard

Biochemical and Functional Characterization of Human Transmembrane Tryptase(TMT)Ttryptase g.

Date

2002

Authors

Wong, Guang

Foster, Paul S

Yasuda, Shinsuke

Qi, Jian

Mahalingam, Surendran

Mellor, Elizabeth

Katsoulotos, Gregory

Li, Lixin

Boyce, Joshua

Krilis, Steven

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

Transmembrane tryptase (TMT)/tryptase γ is a membrane-bound serine protease stored in the secretory granules of human and mouse lung mast cells (MCs). We now show that TMT reaches the external face of the plasma membrane when MCs are induced to degranula