Hypothesis: Biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation

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dc.contributor.authorFranklin, Andrew
dc.contributor.authorBlanden, Robert
dc.date.accessioned2015-12-13T22:42:01Z
dc.date.issued2005
dc.date.updated2015-12-11T10:05:04Z
dc.description.abstractA major function of J-C intronic matrix attachment regions (MAR) during immune diversification via somatic hypermutation (SHM) at immunoglobulin loci may be to manipulate the topology of DNA within the upstream target domain. The suggestion that SHM induction requires MAR-induced torsional strain, in conjunction with DNA remodelling at the J-C intron, completes the definition of a cogent paradigm within which all extant molecular data on the issue may be interpreted. Moreover, the suggestion that a mutagenic mechanism relieves MAR-generated superhelicity could provide an indication as to the evolutionary basis of SHM.
dc.identifier.issn0818-9641
dc.identifier.urihttp://hdl.handle.net/1885/78774
dc.publisherBlackwell Publishing Ltd
dc.sourceImmunology and Cell Biology
dc.subjectKeywords: cytidine deaminase; matrix attachment region binding protein; article; B lymphocyte; DNA supercoiling; gene locus; genetic strain; intron; molecular mechanics; nonhuman; somatic hypermutation; transgenic mouse; Antigens; B-Lymphocytes; Gene Rearrangement, Affinity maturation; Class switch recombination; DNA remodelling; Matrix attachment region; Somatic hypermutation
dc.titleHypothesis: Biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation
dc.typeJournal article
local.bibliographicCitation.issue4
local.bibliographicCitation.lastpage391
local.bibliographicCitation.startpage383
local.contributor.affiliationFranklin, Andrew, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBlanden, Robert, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidFranklin, Andrew, u9913738
local.contributor.authoruidBlanden, Robert, u7100504
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationMigratedxPub7358
local.identifier.citationvolume83
local.identifier.doi10.1111/j.1440-1711.2005.01327.x
local.identifier.scopusID2-s2.0-22944454889
local.type.statusPublished Version

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