Mutations in pfmdr1 Modulate the Sensitivity of Plasmodium falciparum to the Intrinsic Antiplasmodial Activity of Verapamil

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dc.contributor.authorHayward, Rhys
dc.contributor.authorSaliba, Kevin
dc.contributor.authorKirk, Kiaran
dc.date.accessioned2015-12-13T22:57:59Z
dc.date.issued2005
dc.date.updated2015-12-12T07:20:01Z
dc.description.abstractAs well as having the ability to reverse chloroquine resistance in the human malaria parasite Plasmodium falciparum, verapamil has itself an innate antiplasmodial activity. We show here that mutations in Pgh1, the product of the malaria parasite's pfmdr1
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/1885/83222
dc.publisherAmerican Society for Microbiology
dc.sourceAntimicrobial Agents and Chemotherapy
dc.subjectKeywords: chloroquine; halofantrine; mefloquine; verapamil; antibiotic resistance; article; DNA polymorphism; drug activity; drug effect; gene; gene mutation; genetic susceptibility; nonhuman; pfmdr1 gene; Plasmodium falciparum; priority journal; sensitivity analys
dc.titleMutations in pfmdr1 Modulate the Sensitivity of Plasmodium falciparum to the Intrinsic Antiplasmodial Activity of Verapamil
dc.typeJournal article
local.bibliographicCitation.issue2
local.bibliographicCitation.lastpage842
local.bibliographicCitation.startpage840
local.contributor.affiliationHayward, Rhys, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSaliba, Kevin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKirk, Kiaran, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidHayward, Rhys, u3604218
local.contributor.authoruidSaliba, Kevin, u9707744
local.contributor.authoruidKirk, Kiaran, u9608579
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060502 - Infectious Agents
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.absfor111501 - Basic Pharmacology
local.identifier.ariespublicationMigratedxPub11443
local.identifier.citationvolume49
local.identifier.doi10.1128/AAC.49.2.840-842.2005
local.identifier.scopusID2-s2.0-12944300985
local.type.statusPublished Version

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