LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

Xu, Wei; Chooi, Yit-Heng; Choi, Jin W; Li, Shuang; Vederas, John C; Da Silva, Nancy A; Tang, Yi

LovG: The thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis

Date

2013

Authors

Xu, Wei

Chooi, Yit-Heng

Choi, Jin W

Li, Shuang

Vederas, John C

Da Silva, Nancy A

Tang, Yi

Publisher

Wiley-VCH Verlag GMBH

Abstract

No Lov lost: The cryptic thioesterase LovG was found to be responsible for product release from the lovastatin nonaketide synthase (LNKS or LovB; see scheme). LovG also helped improve the turnover of LovB through hydrolysis of incorrectly made intermediat