Plant Importin alpha Binds Nuclear Localization Sequences with High Affinity and Can Mediate Nuclear Import Independent of Importin beta

Hubner, S; Smith, Harley; Hu, Wei; Chan, Chee Kai; Rihs, Hans-Peter; Paschal, Bryce; Raikhel, Natasha; Jans, David A

Plant Importin alpha Binds Nuclear Localization Sequences with High Affinity and Can Mediate Nuclear Import Independent of Importin beta

Date

1999

Authors

Hubner, S

Smith, Harley

Hu, Wei

Chan, Chee Kai

Rihs, Hans-Peter

Paschal, Bryce

Raikhel, Natasha

Jans, David A

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

Nuclear import of conventional nuclear localization sequence (NLS)- containing proteins initially involves recognition by the importin (IMP) α/β heterodimer, where IMPα binds the NLS and IMPβ targets the IMPα/NLS- containing protein complex to the nu