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Selective binding and release of aspirin by an encapsulating receptor

Date

Authors

Nguyen, Thanh

Yoshida, Hiroshi

Sherburn, Michael

Publisher

Royal Society of Chemistry

Abstract

The selective binding of aspirin deep inside superbowl synthetic hosts is reported. Evidence for a two-point binding mode of the drug by the host is presented. Both the strength of aspirin binding and the rate of its release are manipulated by altering the substituents about the host's aperture.

Keywords

Keywords: acetylsalicylic acid; functional group; article; crystal structure; drug binding; drug release; proton nuclear magnetic resonance; X ray crystallography; Aspirin; Crystallography, X-Ray; Drug Carriers; Hydrogen Bonding; Molecular Conformation

URI

http://hdl.handle.net/1885/57424

Collections

ANU Research Publications

Source

Chemical Communications

Type

Journal article

DOI

10.1039/C0CC00422G

Restricted until

2037-12-31

Downloads

File

Description

01_Nguyen_Selective_binding_and_release_2010.pdf (1.19 MB)