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Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

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Date

2006

Authors

Adams, Yvonne
Freeman, Craig
Schwartz-Albiez, Reinhard
Ferro, Vito
Andrews, Katherine
Parish, Christopher

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Microbiology

Abstract

A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.

Description

Keywords

Keywords: antimalarial agent; CD36 antigen; chondroitin 4 sulfate; dextran sulfate; heparan sulfate; hypoxanthine; isomaltotriose; lactitol; maltitol; maltohexaose; maltopentaose; maltose; maltotetrose; maltotriitol; maltotriose; oligosaccharide; panose sulfate; pe

Citation

URI

http://hdl.handle.net/1885/85192

Collections

ANU Research Publications

Source

Antimicrobial Agents and Chemotherapy

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1128/AAC.00313-06

Restricted until

2037-12-31

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01_Adams_Inhibition_of_Plasmodium_2006.pdf (174.97 KB)

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