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Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice

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Date

2013

Authors

Li, Cheryl CY
Young, Paul E
Maloney, Christopher A
Eaton, Sally A
Cowley, Mark J.
Buckland, Michael E
Preiss, Thomas
Henstridge, Darren C
Cooney, Gregory J
Febbraio, Mark

Journal Title

Journal ISSN

Volume Title

Publisher

Landes Bioscience

Abstract

Intrauterine nutrition can program metabolism, creating stable changes in physiology that may have significant health consequences. The mechanism underlying these changes is widely assumed to involve epigenetic changes to the expression of metabolic genes

Description

Keywords

Keywords: leptin; animal experiment; animal model; animal tissue; article; controlled study; copy number variation; diabetes mellitus; DNA methylation; female; gene expression; glucose tolerance test; insulin tolerance test; lipid analysis; liver histology; male; m Avy; Cytosine methylation; Diabetes; Epigenetic programming; Fetal programming; Obesity

Citation

URI

http://hdl.handle.net/1885/73044

Collections

ANU Research Publications

Source

Epigenetics

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.4161/epi.24656

Restricted until

2037-12-31

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Description
01_Li_Maternal_obesity_and_diabetes_2013.pdf (4.64 MB)

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