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Evaluating linkage and linkage disequilibrium: use of excess sharing and transmission disequilibrium methods in affected sib pairs

Date

Authors

Wicks, J

Wilson, Susan

Publisher

Cambridge University Press

Abstract

Two popular and robust approaches to analysing affected sib pair (ASP) data for linkage are the traditional excess sharing methods and the transmission/disequilibrium test (TDT). Here we derive an overall test of linkage for multi-allelic ASP marker data

Keywords

Keywords: allele; article; gene linkage disequilibrium; gene locus; genetic analysis; genetic marker; genetic susceptibility; human; priority journal; probability; risk assessment; sibling; statistical analysis; technique; Genetic Diseases, Inborn; Genetic Predispo

URI

http://hdl.handle.net/1885/23811

Collections

ANU Research Publications

Source

Annals of Human Genetics

Type

Journal article

DOI

10.1017/S0003480000008307

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