Neuronal nitric oxide synthase plays a key role in CNS demyelination

Date

2006

Authors

Linares, David
Taconis, Maaike
Mana, Paula
Correcha, Manuel
Fordham, Susan
Staykova, Maria
Willenborg, David

Journal Title

Journal ISSN

Volume Title

Publisher

Society for Neuroscience

Abstract

Nitric oxide (NO) is a small, short-lived molecule released from a variety of cells that is implicated in a multitude of biological processes. In pathological conditions, overproduction of NO may lead to the generation of highly reactive species, such as

Description

Keywords

Keywords: nitric oxide synthase; peroxynitrite; animal cell; animal experiment; animal model; animal tissue; apoptosis; article; astrocyte; cell damage; cell survival; central nervous system; controlled study; degenerative disease; demyelination; disease model; end Cuprizone; Demyelination; eNOS; nNOS; Oligodendrocytes; Remyelination

Citation

Source

Journal of Neuroscience

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1523/JNEUROSCI.0294-06.2006

Restricted until

2037-12-31