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Neuronal nitric oxide synthase plays a key role in CNS demyelination

Date

Authors

Linares, David

Taconis, Maaike

Mana, Paula

Correcha, Manuel

Fordham, Susan

Staykova, Maria

Willenborg, David

Publisher

Society for Neuroscience

Abstract

Nitric oxide (NO) is a small, short-lived molecule released from a variety of cells that is implicated in a multitude of biological processes. In pathological conditions, overproduction of NO may lead to the generation of highly reactive species, such as

Keywords

Keywords: nitric oxide synthase; peroxynitrite; animal cell; animal experiment; animal model; animal tissue; apoptosis; article; astrocyte; cell damage; cell survival; central nervous system; controlled study; degenerative disease; demyelination; disease model; end Cuprizone; Demyelination; eNOS; nNOS; Oligodendrocytes; Remyelination

URI

http://hdl.handle.net/1885/20480

Collections

ANU Research Publications

Source

Journal of Neuroscience

Type

Journal article

DOI

10.1523/JNEUROSCI.0294-06.2006

Restricted until

2037-12-31

Downloads

File

Description

01_Linares_Neuronal_nitric_oxide_synthase_2006.pdf (699.45 KB)