Terminal Deoxynucleotidyl Transferase Establishes andBroadens Antiviral CD8+ T Cell Immunodominance Hierarchies1
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Haeryfar, S M Mansour
Hickman, Heather D.
Irvine, Kari R
Tscharke, David
Bennink, Jack R
Yewdell, Jonathan W
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American Association of Immunologists
Abstract
The action of TdT on mouse TCR genes accounts for ∼90% of T cell repertoire diversity. We report that in TdT -/- mice, total T CD8+ responses to influenza and vaccinia viruses are reduced by ∼30% relative to wild-type mice. We find that T CD8+ respons
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Journal of Immunology
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2037-12-31
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