Terminal Deoxynucleotidyl Transferase Establishes andBroadens Antiviral CD8+ T Cell Immunodominance Hierarchies1

Date

2008

Authors

Haeryfar, S M Mansour
Hickman, Heather D.
Irvine, Kari R
Tscharke, David
Bennink, Jack R
Yewdell, Jonathan W

Journal Title

Journal ISSN

Volume Title

Publisher

American Association of Immunologists

Abstract

The action of TdT on mouse TCR genes accounts for ∼90% of T cell repertoire diversity. We report that in TdT -/- mice, total T CD8+ responses to influenza and vaccinia viruses are reduced by ∼30% relative to wild-type mice. We find that T CD8+ respons

Description

Keywords

Keywords: DNA nucleotidylexotransferase; epitope; T lymphocyte receptor; virus antigen; lymphocyte antigen receptor; animal cell; animal experiment; animal model; article; CD8+ T lymphocyte; controlled study; immunoreactivity; Influenza virus A; Lymphocytic choriom

Citation

Source

Journal of Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

2037-12-31