Towards the Total Synthesis of 3-Hydroxyvibsanin E
Date
2009
Authors
Schwartz, Brett
Denton, Justin R
Bernhardt, Paul
Davies, Huw ML
Williams, Craig
Journal Title
Journal ISSN
Volume Title
Publisher
Georg Thieme Verlag
Abstract
The synthesis of a silyl-protected derivative of 3-hydroxyvibsanin E has been achieved. The key step is a regio-and stereoselective C-H hydroxylation of an advanced tricyclic intermediate by means of a Rubottom oxidation.
Description
Keywords
Keywords: C-H hydroxylation; Hydroxyvibsanin E; Rubottom oxidation; Stereo-selective; Total synthesis; Hydroxylation; Silanes; Oxidation; 15 o methylcyclovibsanin b; 3 hydroxyvibsanin e; 3 o methylfuranovibsanin a; furanovibsanin a; levo 5 epi vibsanin e; plant ext C-H hydroxylation; Hydroxyvibsanin E; Rubottom oxidation
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Source
Synthesis
Type
Journal article
Book Title
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Restricted until
2037-12-31