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Molecular basis of glutathione synthetase deficiency and a rare gene permutation event

Date

Authors

Board, Philip

Gali, R

Rossjohn, J

Parker, Michael William

Publisher

Oxford University Press

Abstract

Glutathione synthetase (GS) catalyses the production of glutathione from γ-glutamylcysteine and glycine in an ATP-dependent manner. Malfunctioning of GS results in disorders including metabolic acidosis, 5-oxoprolinuria, neurological dysfunction, haemoly

Keywords

Keywords: adenosine diphosphate; adenosine triphosphate; glutathione; glutathione synthase; magnesium ion; sulfate; article; crystal structure; enzyme deficiency; enzyme mechanism; evolution; gene mutation; priority journal; protein secondary structure; sequence ho ATP-grasp superfamily; Genetic disease; Glutathione; Glutathione synthetase; X-ray crystallography

URI

http://hdl.handle.net/1885/92525

Collections

ANU Research Publications

Source

EMBO Journal, The

Type

Journal article

DOI

10.1093/emboj/18.12.3204

Restricted until

2037-12-31

Downloads

File

Description

01_Board_Molecular_basis_of_glutathione_1999.pdf (374.2 KB)

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