Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros Transcription Factor
Date
2003
Authors
Papathanasiou, Panagiotis
Perkins, Andrew C
Cobb, Bradley S
Ferrini, Roger
Sridharan, Rupa
Hoyne, Gerard
Nelms, Keats
Smale, Stephen T
Goodnow, Christopher
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Publisher
Cell Press
Abstract
A central issue in understanding the hematolymphoid system is the generation of appropriate mutant alleles in mice to reveal the function of regulatory genes. Here we describe a mouse strain, Plastic, with a point mutation in a zinc finger of Ikaros that
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Keywords
Keywords: DNA; Ikaros transcription factor; transcription factor; unclassified drug; allele; animal cell; animal experiment; animal tissue; article; cell differentiation; cell maturation; complex formation; controlled study; DNA binding; embryo; embryo development;
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Source
Immunity
Type
Journal article
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2037-12-31
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