Synthesis of NTA 3 -DTDA - A Chelator-Lipid that Promotes Stable Binding of His-Tagged Proteins to Membranes

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dc.contributor.authorAltin, Joseph
dc.contributor.authorBanwell, Martin
dc.contributor.authorCoghlan, Phillip
dc.contributor.authorEaston, Christopher
dc.contributor.authorNairn, Michael
dc.contributor.authorOffermann, Daniel
dc.date.accessioned2015-12-13T23:02:35Z
dc.date.issued2006
dc.date.updated2015-12-12T07:48:08Z
dc.description.abstractA six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.
dc.identifier.issn0004-9425
dc.identifier.urihttp://hdl.handle.net/1885/84959
dc.publisherCSIRO Publishing
dc.sourceAustralian Journal of Chemistry
dc.subjectKeywords: Antigens; Cells; Chelation; Dendrimers; Spectroscopic analysis; Tumors; Anti-tumour responses; Dendritic-type compound; Liposomes; Membrane-penetrating; Plasma membrane; Lipids
dc.titleSynthesis of NTA 3 -DTDA - A Chelator-Lipid that Promotes Stable Binding of His-Tagged Proteins to Membranes
dc.typeJournal article
local.bibliographicCitation.issue5
local.bibliographicCitation.lastpage306
local.bibliographicCitation.startpage302
local.contributor.affiliationAltin, Joseph, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBanwell, Martin, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationCoghlan, Phillip, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationEaston, Christopher, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationNairn, Michael, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationOffermann, Daniel, College of Physical and Mathematical Sciences, ANU
local.contributor.authoruidAltin, Joseph, u4235798
local.contributor.authoruidBanwell, Martin, u9500594
local.contributor.authoruidCoghlan, Phillip, u960646
local.contributor.authoruidEaston, Christopher, u9500570
local.contributor.authoruidNairn, Michael, u4054134
local.contributor.authoruidOffermann, Daniel, u4251551
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationMigratedxPub13173
local.identifier.citationvolume59
local.identifier.doi10.1071/CH06112
local.identifier.scopusID2-s2.0-33745025037
local.type.statusPublished Version

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