Synthesis of NTA 3 -DTDA - A Chelator-Lipid that Promotes Stable Binding of His-Tagged Proteins to Membranes
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Altin, Joseph
Banwell, Martin
Coghlan, Phillip
Easton, Christopher
Nairn, Michael
Offermann, Daniel
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CSIRO Publishing
Abstract
A six-step reaction sequence is described for the preparation of compound 1 (NTA3-DTDA), a membrane-penetrating and potent chelator that can be incorporated into liposomes and plasma membrane vesicles containing antigens and thus allowing targeted delivery of such assemblies to a variety of cells for the purposes of eliciting anti-tumour responses. Full spectroscopic characterization of this dendritic-type compound as well as certain of its precursors is reported.
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Australian Journal of Chemistry
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2037-12-31
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