PEO-PPO-PEO surfactant exfoliated graphene cyclodextrin drug carriers for photoresponsive release

Date

2018

Authors

Quinn, Matthew D. J.
Wang, Tao
Al Kobaisi, Mohammad
Craig, Vincent S. J.
Notley, Shannon

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Liquid exfoliated graphene sheets were incorporated within α-cyclodextrin-triblock copolymer supramolecular hydrogels prepared with a range of polyethylene oxide and polypropylene oxide block sizes and ratios allowing control over the release properties. The strong photothermal activity of graphene was employed to externally activate drug release from within the gels using near-infrared (NIR) irradiation. These supramolecular hybrid hydrogels showed thermoreversible changes in viscosity, which is necessary for an injectable, multiple release point drug delivery depot. This hybrid graphene-surfactant-α-CD gel system with thermoreversible properties is demonstrated herein to be externally NIR activated to induce controllable drug release.

Description

Keywords

Photothermal, Graphene, Hydrogel, Near-infrared, 2D, Drug release

Citation

Source

Materials Chemistry and Physics

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1016/j.matchemphys.2017.11.012

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