On the modelling of a bistable genetic switch

Abstract

A bistable switch is a common motif in a genetic regulatory network. There have been relatively few in vivo measurements made of such a network. Its natural closed loop nature makes the living switch difficult to measure experimentally. Hence not much have been reported on derivation of a model from in vivo data, which is expected to be different from the macroscopic scale in vitro measurements. We present a heuristic for modelling a naturally occurring switch from relatively few in vivo experimental data points, yielding a model suited to dynamical simulation, and give predictions of the unmeasured protein in the system. Show more