A Chemoenzymatic Total Synthesis of the Phytotoxic Undecenolide (-)-Cladospolide A
Date
2004
Authors
Banwell, Martin
Loong, David
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
An eleven-step synthesis of the title compound (1) from biocatalytically-derived and enantiomerically pure 'building blocks' alcohol (R)-(-)-9 and ester 13 is described. Attempts to construct the twelve-membered lactone ring of cladospolide A in a direct
Description
Keywords
Keywords: Biocatalysts; Chromatography; Enzymes; Filtration; Hydrogenation; Stereochemistry; Synthesis (chemical); X ray analysis; Allylic alcohols; Necrosis; Retrosynthetic analysis; Ring-closing metathesis (RCM); Amino acids; Alia; cladospolide a; cladospolide B;
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Source
Organic and Biomolecular Chemistry
Type
Journal article