Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Double-Mannich annulation of cyclic ketones using N,N-bis(ethoxymethyl)alkylamine reagents

Date

Authors

Halliday, Jill I

Chebib, Mary

Turner, Peter

McLeod, Malcolm

Publisher

American Chemical Society

Abstract

N,N-Bis(ethoxymethyl)alkylamines function as effective reagents in the double-Mannich annulation of cyclic ketone substrates, providing efficient access to a series of azabicyclic ketones. These ring systems are a useful scaffold for the four-step synthesis of novel constrained homocholine analogues.

Keywords

Keywords: amine; choline; drug derivative; dyes, reagents, indicators, markers and buffers; fused heterocyclic rings; heterocyclic compound; homocholine; ketone; article; catalysis; chemical structure; chemistry; synthesis; Amines; Aza Compounds; Bicyclo Compounds,

URI

http://hdl.handle.net/1885/52811

Collections

ANU Research Publications

Source

Organic Letters

Type

Journal article

DOI

10.1021/ol061242s

Restricted until

2037-12-31

Downloads

File

Description

01_Halliday_Double-Mannich_annulation_of_2006.pdf (73.6 KB)