Mechanisms of Amyloid β Protein-Induced Modification in Ion Transport Systems: Implications for Neurodegenerative Diseases

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Date

2001

Authors

Kourie, Joseph

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Volume Title

Publisher

Kluwer Academic Publishers

Abstract

1. Alzheimer's disease (AD) is a neurodegenerative disorder that affects the cognitive function of the brain. Pathological changes in AD are characterized by the formation of amyloid plaques and neurofibrillary tangles as well as extensive neuronal loss.

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Keywords

Keywords: adenosine triphosphatase (potassium sodium); adenosine triphosphate; amyloid beta protein; calcium channel; calcium ion; chloride channel; chloride ion; potassium channel; potassium ion; reactive oxygen metabolite; sodium channel; sodium ion; Alzheimer di Alzheimer's disease; Beta amyloid; Ion channel diseases; Membrane physiology; Neurodegeneration; Neurofibrillary tangles; Protein aggregation; Senile plaques

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URI

http://hdl.handle.net/1885/66127

Collections

ANU Research Publications

Source

Cellular and Molecular Neurobiology

Type

Journal article

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DOI

10.1023/A:1010932603406

Restricted until

2037-12-31

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