Exploiting 4-1BB costimulation for enhancing antiviral vaccination
Date
2006
Authors
Harrison, Jodie
Bertram, Edward
Ramshaw, Ian
Journal Title
Journal ISSN
Volume Title
Publisher
Mary Ann Liebert Inc.
Abstract
4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8+ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8+ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.
Description
Keywords
Keywords: CD137 antigen; CD28 antigen; monoclonal antibody; tumor necrosis factor receptor; virus vaccine; antibody response; CD4+ T lymphocyte; CD8+ T lymphocyte; cytokine production; human; immunoregulation; innate immunity; lymphocyte proliferation; nonhuman; pr
Citation
Collections
Source
Viral Immunology
Type
Journal article