Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study
Date
Authors
Swaminathan, Ashwin
Harrison, Simone
Ketheesan, Natkunam
van den Boogaard, Christel H A
Dear, Keith
Allen, Martin
Hart, Prue
Cook, Matthew
Lucas, Robyn
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Animal and human studies show that exposure to solar-simulated ultraviolet radiation (UVR) is immunomodulatory. Human studies using natural sun exposure and controlling for confounding are rare. We immunised 217 healthy adults (18-40 years) with a T-cell dependent antigen, keyhole limpet haemocyanin (KLH) and measured personal clothing-adjusted UVR (ca-UVR) exposure (for five days before and after immunisation), lifetime cumulative UVR exposure, serum 25-hydroxyvitamin D (25(OH)D) concentration at immunisation, and potential confounding factors.
Description
Keywords
Citation
Collections
Source
The Journal of Investigative Dermatology
Type
Book Title
Entity type
Access Statement
Open Access
License Rights
Creative Commons Attribution Non-Commercial No Derivatives 4.0 International
Restricted until
Downloads
File
Description