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Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis

Date

2013

Authors

Tjhin, Erick
Staines, Henry M.
Van Schalkwyk, Donelly
Krishna, Sanjeev
Saliba, Kevin

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

To characterise plasmodial glycolysis, we generated two transgenic Plasmodium falciparum lines, one expressing P. falciparum hexokinase (PfHK) tagged with GFP (3D7-PfHKGFP) and another overexpressing native PfHK (3D7-PfHK+). Contrary to previous reports,

Description

Keywords

Keywords: deoxyglucose; glucose; glucose transporter; hexokinase; article; cellular distribution; controlled study; cytosol; enzyme activity; glucose transport; glycolysis; nonhuman; Plasmodium falciparum; priority journal; transgenic organism; Glucose; Hexokinase; Glucose; Hexokinase; Hexose transport; Malaria; Plasmodium

Citation

Source

FEBS Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.febslet.2013.07.052

Restricted until

2037-12-31