Cerebellarcortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophrenia

Simple item page
dc.contributor.authorKim, Dae-Jin
dc.contributor.authorMoussa-Tooks, Alexandra B
dc.contributor.authorBolbecker, Amanda
dc.contributor.authorApthorp, Deborah
dc.contributor.authorNewman, Sharlene
dc.contributor.authorO'Donnell, Brian F
dc.contributor.authorHetrick, William
dc.date.accessioned2024-05-10T00:18:45Z
dc.date.available2024-05-10T00:18:45Z
dc.date.issued2020
dc.date.updated2023-01-15T07:16:31Z
dc.description.abstractAbnormalities of cerebellar function have been implicated in the pathophysiology of schizophrenia. Since the cerebellum has afferent and efferent projections to diverse brain regions, abnormalities in cerebellar lobules could affect functional connectivity with multiple functional systems in the brain. Prior studies, however, have not examined the relationship of individual cerebellar lobules with motor and nonmotor resting-state functional networks. We evaluated these relationships using resting-state fMRI in 30 patients with a schizophrenia-spectrum disorder and 37 healthy comparison participants. For connectivity analyses, the cerebellum was parcellated into 18 lobular and vermal regions, and functional connectivity of each lobule to 10 major functional networks in the cerebrum was evaluated. The relationship between functional connectivity measures and behavioral performance on sensorimotor tasks (i.e., finger-tapping and postural sway) was also examined. We found cerebellar-cortical hyperconnectivity in schizophrenia, which was predominantly associated with Crus I, Crus II, lobule IX, and lobule X. Specifically, abnormal cerebellar connectivity was found to the cerebral ventral attention, motor, and auditory networks. This cerebellar-cortical connectivity in the resting-state was differentially associated with sensorimotor task-based behavioral measures in schizophrenia and healthy comparison participants-that is, dissociation with motor network and association with nonmotor network in schizophrenia. These findings suggest that functional association between individual cerebellar lobules and the ventral attentional, motor, and auditory networks is particularly affected in schizophrenia. They are also consistent with dysconnectivity models of schizophrenia suggesting cerebellar contributions to a broad range of sensorimotor and cognitive operationsen_AU
dc.description.sponsorshipBrain and Behavior Research Foundation;Indiana Clinical and Translational SciencesInstitute, Grant/Award Numbers: TL1TR001107, UL1 TR001108; National Instituteof Mental Health, Grant/Award Numbers: R01MH074983, R21 MH091774, T32 MH103213en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1065-9471en_AU
dc.identifier.urihttp://hdl.handle.net/1885/317412
dc.language.isoen_AUen_AU
dc.provenanceThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.en_AU
dc.publisherJohn Wiley & Sons Inc.en_AU
dc.rights© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.en_AU
dc.rights.licenseCreative Commons Attribution 4.0 International Licenseen_AU
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceHuman Brain Mappingen_AU
dc.subjectcerebellumen_AU
dc.subjectfunctional connectivityen_AU
dc.subjectschizophreniaen_AU
dc.subjectfinger tappingen_AU
dc.subjectpostural swayen_AU
dc.titleCerebellarcortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophreniaen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue11en_AU
local.bibliographicCitation.lastpage3132en_AU
local.bibliographicCitation.startpage3119en_AU
local.contributor.affiliationKim, Dae-Jin, Indiana Universityen_AU
local.contributor.affiliationMoussa-Tooks, Alexandra B, Indiana Universityen_AU
local.contributor.affiliationBolbecker, Amanda, Indiana Universityen_AU
local.contributor.affiliationApthorp, Deborah, College of Engineering, Computing and Cybernetics, ANUen_AU
local.contributor.affiliationNewman, Sharlene, Indiana Universityen_AU
local.contributor.affiliationO'Donnell, Brian F, Indiana Universityen_AU
local.contributor.affiliationHetrick, William, Indiana Universityen_AU
local.contributor.authoremailu5331246@anu.edu.auen_AU
local.contributor.authoruidApthorp, Deborah, u5331246en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor520100 - Applied and developmental psychologyen_AU
local.identifier.ariespublicationa383154xPUB11384en_AU
local.identifier.citationvolume41en_AU
local.identifier.doi10.1002/hbm.25002en_AU
local.identifier.scopusID2-s2.0-85082952207
local.identifier.thomsonIDWOS:000545713400017
local.identifier.uidSubmittedBya383154en_AU
local.publisher.urlhttps://www.wiley.com/en-gben_AU
local.type.statusPublished Versionen_AU

Downloads

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Human Brain Mapping - 2020 - Kim - Cerebellar cortical dysconnectivity in resting‐state associated with sensorimotor tasks.pdf
Size:
2.62 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2024 LYRASIS