Incorporation of chlorinated analogues of aliphatic amino acids during cell-free protein synthesis
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Stigers, Dannon
Watts, Zachary
Hennessy, James E
Kim, Hye-Kyung
Martini, Romeo
Taylor, Matthew C
Ozawa, Kiyoshi
Keillor, Jeffrey W
Dixon, Nicholas Edward
Easton, Christopher
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Royal Society of Chemistry
Abstract
3-Chloro-Abu and 4-chloro-Nva are biosynthetically incorporated into E. coli peptidyl-Pro cis-trans isomerase B, as substitutes for Val and Leu, respectively. The extent of incorporation is up to ∼90%, and substituted protein is catalytically active. By
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Chemical Communications
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2037-12-31
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