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Computational Studies of Venom Peptides Targeting Potassium Channels

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dc.contributor.authorChen, Rong
dc.contributor.authorChung, Shin-Ho
dc.date.accessioned2018-11-29T22:57:08Z
dc.date.available2018-11-29T22:57:08Z
dc.date.issued2015
dc.date.updated2018-11-29T08:15:56Z
dc.description.abstractSmall peptides isolated from the venom of animals are potential scaffolds for ion channel drug discovery. This review article mainly focuses on the computational studies that have advanced our understanding of how various toxins interfere with the function of K+ channels. We introduce the computational tools available for the study of toxin-channel interactions. We then discuss how these computational tools have been fruitfully applied to elucidate the mechanisms of action of a wide range of venom peptides from scorpions, spiders, and sea anemone. Keywords: potassium channels; peptide toxins; molecular modeling; molecular dynamics
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2072-6651
dc.identifier.urihttp://hdl.handle.net/1885/153754
dc.publisherOpen Access
dc.sourceToxins
dc.titleComputational Studies of Venom Peptides Targeting Potassium Channels
dc.typeJournal article
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue12
local.bibliographicCitation.lastpage5211
local.bibliographicCitation.startpage5194
local.contributor.affiliationChen, Rong, College of Science, ANU
local.contributor.affiliationChung, Shin-Ho, College of Science, ANU
local.contributor.authoruidChen, Rong, u5056585
local.contributor.authoruidChung, Shin-Ho, u8809509
local.description.notesImported from ARIES
local.identifier.absfor060112 - Structural Biology (incl. Macromolecular Modelling)
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationu4008405xPUB111
local.identifier.citationvolume7
local.identifier.doi10.3390/toxins7124877
local.identifier.scopusID2-s2.0-84949057806
local.identifier.thomsonID000367013500023
local.type.statusPublished Version

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