The downregulation of FLOWERING LOCUS C (FLC) expression in plants with low levels of DNA methylation and by vernalization occurs by distinct mechanisms

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dc.contributor.authorFinnegan, E. Jean
dc.contributor.authorKovac, Kathryn
dc.contributor.authorJaligot, Estelle
dc.contributor.authorSheldon, Candice
dc.contributor.authorPeacock, W James
dc.contributor.authorDennis, Elizabeth
dc.date.accessioned2015-12-13T23:02:03Z
dc.date.issued2005
dc.date.updated2015-12-12T07:44:30Z
dc.description.abstractFLOWERING LOCUS C (FLC), a repressor of flowering, is a major determinant of flowering time in Arabidopsis. FLC expression is repressed by vernalization and in plants with low levels of DNA methylation, resulting in early flowering. This repression is not associated with changes of DNA methylation within the FLC locus in either vernalized q5plants or plants with low levels of DNA methylation. In both cases, there is a reduction of histone H3 trimethyl-lysine 4 (K4) and acetylation of both histones H3 and H4 around the promoter-translation start of FLC. The expression of the two genes flanking FLC is also repressed in both conditions and repression is associated with decreased histone H3 acetylation. The changes in histone modifications at the FLC gene cluster, which are similar in vernalized plants and in plants with reduced DNA methylation, must arise by different mechanisms. VERNALIZATION 1, VERNALIZATION 2 and VERNALIZATION INSENSITIVE 3q6 modulate FLC expression in vernalized plants; these proteins play no role in the downregulation of FLC in plants with low levels of DNA methylation. Chimeric FLC
dc.identifier.issn0960-7412
dc.identifier.urihttp://hdl.handle.net/1885/84710
dc.publisherBlackwell Publishing Ltd
dc.sourceThe Plant Journal
dc.subjectKeywords: DNA; Genes; Ketones; Chromatin immunoprecipitation; DNA methylation; Histone acetylation; VIN3; VRN1; Plants (botany); Genes; Ketones; Nucleic Acids; Plants; Arabidopsis; Arabidopsis protein; DNA binding protein; FLF protein, Arabidopsis; histone; MADS do Chromatin immunoprecipitation; DNA methylation; Histone acetylation; Vernalization; VIN3; VRN1
dc.titleThe downregulation of FLOWERING LOCUS C (FLC) expression in plants with low levels of DNA methylation and by vernalization occurs by distinct mechanisms
dc.typeJournal article
local.bibliographicCitation.lastpage32
local.bibliographicCitation.startpage420
local.contributor.affiliationFinnegan, E. Jean, CSIRO
local.contributor.affiliationKovac, Kathryn, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJaligot, Estelle, CSIRO
local.contributor.affiliationSheldon, Candice, CSIRO
local.contributor.affiliationPeacock, W James, CSIRO Division of Plant Industry
local.contributor.affiliationDennis, Elizabeth, CSIRO
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidKovac, Kathryn, u9517451
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060199 - Biochemistry and Cell Biology not elsewhere classified
local.identifier.ariespublicationMigratedxPub12967
local.identifier.citationvolume44
local.identifier.doi10.1111/j.1365-313X.2005.02541.x
local.identifier.scopusID2-s2.0-33644753234
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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