[Review] A Second Wave for the Neurokinin Tac2 Pathway in Brain Research

Date

2021

Authors

Al Abed, A. Shaam
Reynolds, Nathan
Dehorter, Nathalie

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Despite promising advances in basic research of the neurokinin B/Tac2 pathway in both animals and humans, clinical applications are yet to be implemented. This is likely because of our limited understanding of the action of the pathway in the brain. While this system controls neuronal activity in multiple regions, the precise impact of Tac2-induced cellular responses on behavior remains unclear. Recently, elegant studies revealed a key contribution to stress-related behaviors and memory. Here, we discuss the crucial importance of bridging the gap between the Tac2 pathway's involvement in cell physiology and cognition to comprehend its role in health and disease. We propose that a better understanding of the Tac2 pathway in the brain could provide an essential perspective for basic investigations, which in turn will feed clinical research.

Description

Keywords

Cognition, GPCR, Neuromodulation, Neuropeptide, Pathology, Stress

Citation

Source

Biological Psychiatry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.biopsych.2021.02.016

Restricted until

2099-12-31