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Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704

Date

Authors

Farrell, James

Bae, K.

Wong, J.

Guha, C.

Dicker, Adam

Elsaleh, Hany

Publisher

Nature Publishing Group

Abstract

The aim of this study is to validate the prognostic and predictive value of the non-synonymous cytidine deaminase (CDA) Lys27 Gln polymorphism for hematological toxicity and survival using a randomized phase III adjuvant trial (Radiation Therapy Oncology

Keywords

Keywords: cytidine deaminase; fluorouracil; gemcitabine; glutamine; lysine; adjuvant chemotherapy; adult; aged; article; blood toxicity; cancer prognosis; cancer radiotherapy; cancer survival; continuous infusion; controlled study; disease marker; disease severity; cancer; cytidine deaminase; gemcitabine; pancreatic cancer; pharmacogenomics

URI

http://hdl.handle.net/1885/69608

Collections

ANU Research Publications

Source

Pharmacogenomics Journal

Type

Journal article

DOI

10.1038/tpj.2011.22

Restricted until

2037-12-31

Downloads

File

Description

01_Farrell_Cytidine_deaminase_2012.pdf (138.76 KB)

02_Farrell_Cytidine_deaminase_2012.pdf (107.82 KB)