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Peptide fragments of the dihydropyridine receptor can modulate cardiac ryanodine receptor channel activity and sarcoplasmic reticulum Ca2+ release

Date

2004

Authors

Dulhunty, Angela
Curtis, Suzanne
Cengia, Louise
Sakowska, Magdalena
Casarotto, Marco

Journal Title

Journal ISSN

Volume Title

Publisher

Portland Press

Abstract

We show that peptide fragments of the dihydropyridine receptor II-III loop alter cardiac RyR (ryanodine receptor) channel activity in a cytoplasmic Ca 2+-dependent manner. The peptides were Ac (Thr-793-Ala-812 of the cardiac dihydropyridine receptor), As

Description

Keywords

Keywords: Biochemistry; Cytology; Lipids; Nuclear magnetic resonance; Plasmas; Cytoplasmic; Helical; Peptide fragments; Sarcoplasmic; Cardiology; 1,4 dihydropyridine receptor; alanine; heart receptor; ion channel; leucine; peptide fragment; protein subunit; threoni Cardiac ryanodine receptor activity; Dihydropyridine receptor; Muscle contraction; Ryanodine receptor probe

Citation

Source

Biochemical Journal

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1042/BJ20031096

Restricted until

2037-12-31