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Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation

Date

Authors

Zabala, Angelica O.

Xu, Wei

Chooi, Yit-Heng

Tang, Yi

Publisher

Elsevier

Abstract

Azaphilones are a class of fungal metabolites characterized by a highly oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of bioactivities. Although widespread among various fungi, their biosynthesis has not been thoroughly elucidated.

Keywords

Keywords: azanigerone A; azanigerone B; azanigerone C; azanigerone D; azanigerone E; azanigerone F; azaphilone derivative; benzaldehyde; bicyclo compound; flavin dependent monooxygenase; polyketide synthase; pyran; quinone derivative; unclassified drug; unspecific

URI

http://hdl.handle.net/1885/80487

Collections

ANU Research Publications

Source

Chemistry and Biology

Type

Journal article

DOI

10.1016/j.chembiol.2012.07.004

Restricted until

2037-12-31

Downloads

File

Description

01_Zabala_Characterization_of_a_silent_2012.pdf (983.44 KB)