T Cell determinants incorporating β -amino acid residues are protease resistant and remain immunogenic in vivo
Date
2005
Authors
Webb, Andrew
Dunstone, Michelle
Williamson, Nicholas
Price, Jason
de Kauwe, Andrea
Chen, Weisan
Oakley, Aaron
Perlmutter, Patrick
McCluskey, James
Aguilar, Marie-Isabel
Journal Title
Journal ISSN
Volume Title
Publisher
American Association of Immunologists
Abstract
A major hurdle in designing successful epitope-based vaccines resides in the delivery, stability, and immunogenicity of the peptide immunogen. The short-lived nature of unmodified peptide-based vaccines in vivo limits their therapeutic application in the
Description
Keywords
Keywords: antigen; beta amino acid; cross reacting antigen; proteinase; vaccine; amino acid analysis; animal cell; article; cancer immunotherapy; controlled study; drug design; enzyme stability; epitope mapping; immunogenicity; immunoprophylaxis; in vivo study; maj
Citation
Collections
Source
Journal of Immunology
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
DOI
Restricted until
2037-12-31
Downloads
File
Description