Chemical and genetic validation of thiamine utilization as an antimalarial drug target
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Chan, Xie
Wrenger, Carsten
Stahl, Katharina
Bergmann, Barbel
Winterberg, Markus
Muller, Ingrid B
Saliba, Kevin
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Macmillan Publishers Ltd
Abstract
Thiamine is metabolized into an essential cofactor for several enzymes. Here we show that oxythiamine, a thiamine analog, inhibits proliferation of the malaria parasite Plasmodium falciparum in vitro via a thiamine-related pathway and significantly reduce
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Nature Communications
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