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Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle

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Date

2012

Authors

Barrientos, Genaro C
Feng, Wei
Truong, Kim
Matthaei, Klaus
Yang, Tianzhong
Allen, Paul D
Lopez, Jose R
Pessah, Issac N

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

Malignant hyperthermia susceptibility (MHS) is primarily conferred by mutations within ryanodine receptor type 1 (RYR1). Here we address how the MHS mutation T4826I within the S4-S5 linker influences excitation-contraction coupling and resting myoplasmic

Description

Keywords

Keywords: Binding analysis; Calcium channels; Calpains; Electrical stimuli; Excitation-contraction coupling; In-vivo; Malignant hyperthermias; Myotubes; Oxygen consumption rate; Rank order; Ryanodine; Ryanodine receptor type 1; Sarcoplasmic reticulum; Single channe

Citation

URI

http://hdl.handle.net/1885/54305

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1074/jbc.M111.307926

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